Recently, DNSSEC has been rolling out into major DNS servers, including those that service the .org zone and now the root zone. This sounds at first glance like a good thing: all responses from DNS servers are validated, and it becomes impossible for man-in-the-middle attacks to take place.
The main problem (for this discussion) is that DNSSEC completely removes the possibility of a man-in-the-middle – that is, it is impossible for a DNS server like OpenDNS to return a different IP address than the actual DNS address of a machine.
The OpenDNS article also suggests that Akimai and the NTP Pool Project will both be affected by this as well. In these cases, the problem is that when a name is presented to the DNS server, it chooses a particular IP address based on parameters of its choosing – so a one-to-one mapping of DNS name to IP address is irrelevant and impossible.
This also suggests that DNS round robin for clusters would be impossible to implement with DNSSEC active as well.
It will be interesting to see what becomes of DNSSEC if commercial interests like OpenDNS and Akimai speak out against it.